ivive.app

Connect Remote server

claude mcp add --transport http ivive https://api.ivive.app/mcp/

{
  "mcpServers": {
    "ivive": {
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

{
  "servers": {
    "ivive": {
      "type": "http",
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

Settings > Connectors > Add custom connector
URL: https://api.ivive.app/mcp/

Tools 6 found in our last check

• predict_inputs

  Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.

• calc_clhep

  Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.

• target_clint

  The in-vitro CLint an assay must read for a compound to reach a target plasma clearance (mL/min/kg): calc_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that c…

• input_sensitivity

  How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.

• similar_drugs

  Nearest reference drugs to a SMILES (Tanimoto, Morgan radius 2), each with measured human plasma CL and the CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc_clhep for this chemotype: if IVIVE missed on the neighbours, expect it to miss here. Ret…

• scale_to_human

  Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.

Details

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