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Rosetta Mcp Server

io.github.Arielbs/rosetta-mcp-server ยท v1.3.1

Rosetta/PyRosetta protein modeling and Biotite translation for computational biology

Source code Set it up

Connect Runs on your machine

Terminal
claude mcp add rosetta-mcp-server -e ROSETTA_BIN=<ROSETTA_BIN> -e PYTHON_BIN=<PYTHON_BIN> -e MCP_DEBUG=<MCP_DEBUG> -- npx -y [email protected]
claude_desktop_config.json
{
  "mcpServers": {
    "rosetta-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "[email protected]"
      ],
      "env": {
        "ROSETTA_BIN": "<ROSETTA_BIN>",
        "PYTHON_BIN": "<PYTHON_BIN>",
        "MCP_DEBUG": "<MCP_DEBUG>"
      }
    }
  }
}
~/.cursor/mcp.json
{
  "mcpServers": {
    "rosetta-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "[email protected]"
      ],
      "env": {
        "ROSETTA_BIN": "<ROSETTA_BIN>",
        "PYTHON_BIN": "<PYTHON_BIN>",
        "MCP_DEBUG": "<MCP_DEBUG>"
      }
    }
  }
}
.vscode/mcp.json
{
  "servers": {
    "rosetta-mcp-server": {
      "type": "stdio",
      "command": "npx",
      "args": [
        "-y",
        "[email protected]"
      ],
      "env": {
        "ROSETTA_BIN": "<ROSETTA_BIN>",
        "PYTHON_BIN": "<PYTHON_BIN>",
        "MCP_DEBUG": "<MCP_DEBUG>"
      }
    }
  }
}

Replace the values in angle brackets with your own. Keys stay on your machine; we never see them.

Tools

This server runs locally, so its tools are listed by your MCP client once it starts.

Environment variables

NameDescription
ROSETTA_BIN
Optional		Path to rosetta_scripts binary or its directory
PYTHON_BIN
Optional		Python interpreter with PyRosetta/Biotite installed
MCP_DEBUG
Optional		Set to 1 for debug logging

Details

Package[email protected] (NPM, stdio)
First published3 Apr 2026
Last updated3 Apr 2026
Registry nameio.github.Arielbs/rosetta-mcp-server

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