Search InterPro entries, map domains onto proteins and PDB structures, and scan raw sequences.
Connect Remote server
claude mcp add --transport http interpro-mcp-server https://interpro.caseyjhand.com/mcp
{
"mcpServers": {
"interpro-mcp-server": {
"url": "https://interpro.caseyjhand.com/mcp"
}
}
}
{
"servers": {
"interpro-mcp-server": {
"type": "http",
"url": "https://interpro.caseyjhand.com/mcp"
}
}
}
Settings > Connectors > Add custom connector
URL: https://interpro.caseyjhand.com/mcp
Tools 9 found in our last check
interpro_list_referenceList supported InterPro database slugs, entry types, accession and PDB identifier patterns, common taxon IDs, or current release information.
interpro_search_entriesSearch InterPro entries or member signatures by text or entry type. GO filters require sourceDatabase interpro; integratedInto selects member signatures for an InterPro accession. Results are cursor-paged; use interpro_get_entry for full metadata.
interpro_get_entryRetrieve one InterPro or member-database entry with full metadata by default. Select optional sections while retaining core and unknown metadata, or supply overlapLimit to page whole overlap records in upstream order; offsets are not a snapshot across calls.
interpro_get_clanRetrieve a Pfam, CDD, or PIRSF clan/set and a cursor page of member entries; optionally include its relationship graph, returned in slices that fit the response budget and paged with relationshipOffset.
interpro_get_protein_domainsRetrieve InterPro and member-signature matches on a canonical UniProt protein, preserving every location and discontinuous fragment. Optionally select records covering a residue, include extra predicted features, and include functional residue rules with provenance. Budgeted seg…
interpro_find_proteins_by_domainFind UniProt proteins carrying an InterPro or member signature. Defaults to reviewed human proteins; reviewedOnly=false includes all review statuses in the chosen taxon. Optional isFragment filters fragment annotations; false does not prove sequence completeness. architectureId…
interpro_get_structure_domainsRetrieve InterPro and member-signature matches on one PDB entry's protein chains. Each chain record keeps match locations in chain numbering (1-based start/end beside author auth_start/auth_end, which can be null), in UniProt numbering, and the chain-to-UniProt residue map, with…
interpro_scan_sequenceFind InterPro domain, family, and site matches for one raw protein sequence that has no UniProt accession. Sequences already in UniParc return precalculated matches at once; any other sequence starts one InterProScan 6 job, which commonly runs about ten minutes, so the usual fir…
interpro_get_scan_resultCheck an InterProScan job started by interpro_scan_sequence, waiting up to waitSeconds for it to finish. Returns the matches once finished, otherwise its queued or running status to check again later. Matches are InterProScan records verbatim, 1-based and inclusive, with the Int…
Details
| Endpoint | https://interpro.caseyjhand.com/mcp (Streamable HTTP) |
| Package | @cyanheads/[email protected] (NPM, stdio) |
| Package | @cyanheads/[email protected] (NPM, streamable-http) |
| First published | 28 Oct 2026 |
| Last updated | 28 Oct 2026 |
| Registry name | io.github.cyanheads/interpro-mcp-server |
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