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Cytoscape Desktop MCP

io.github.cytoscape/cytoscape-desktop-mcp-bridge · v1.0.3

Drive a running Cytoscape Desktop to load, lay out, and style biological networks.

Connect Runs on your machine

Terminal
claude mcp add cytoscape-desktop-mcp-bridge -e CYREST_PORT=<CYREST_PORT> -- https://github.com/cytoscape/cytoscape-desktop-mcp/releases/download/mcpb-v1.0.3/cytoscape-mcp.mcpb
claude_desktop_config.json
{
  "mcpServers": {
    "cytoscape-desktop-mcp-bridge": {
      "command": "https://github.com/cytoscape/cytoscape-desktop-mcp/releases/download/mcpb-v1.0.3/cytoscape-mcp.mcpb",
      "args": [],
      "env": {
        "CYREST_PORT": "<CYREST_PORT>"
      }
    }
  }
}
~/.cursor/mcp.json
{
  "mcpServers": {
    "cytoscape-desktop-mcp-bridge": {
      "command": "https://github.com/cytoscape/cytoscape-desktop-mcp/releases/download/mcpb-v1.0.3/cytoscape-mcp.mcpb",
      "args": [],
      "env": {
        "CYREST_PORT": "<CYREST_PORT>"
      }
    }
  }
}
.vscode/mcp.json
{
  "servers": {
    "cytoscape-desktop-mcp-bridge": {
      "type": "stdio",
      "command": "https://github.com/cytoscape/cytoscape-desktop-mcp/releases/download/mcpb-v1.0.3/cytoscape-mcp.mcpb",
      "args": [],
      "env": {
        "CYREST_PORT": "<CYREST_PORT>"
      }
    }
  }
}

Replace the values in angle brackets with your own. Keys stay on your machine; we never see them.

Tools

This server runs locally, so its tools are listed by your MCP client once it starts.

Environment variables

NameDescription
CYREST_PORT
Optional
Port Cytoscape Desktop's REST interface listens on (Edit > Preferences > REST API)

Details

Packagehttps://github.com/cytoscape/cytoscape-desktop-mcp/releases/download/mcpb-v1.0.3/cytoscape-mcp.mcpb (MCPB, stdio)
Package@cytoscape/[email protected] (NPM, stdio)
First published11 Aug 2026
Last updated11 Aug 2026
Registry nameio.github.cytoscape/cytoscape-desktop-mcp-bridge

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